Protein Details: Short transient receptor potential channel 4

Protein ID

ICDB_Pro_0698

Protein Name

Short transient receptor potential channel 4

Gene Name

TRPC4

Organism

Bos taurus (Bovine)

Length

979 amino acids

AlphaFoldDB

AF-P79100-F1-model_v4.pdb

Function

Sequence

MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLLEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIVGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTVQSAQGTKESSNSADSDEKSDNEGSSKDKKKNFSLFDLTTLIHPRSAAIAAERHTISNGSALVVQEPPREKQRKVNFVTDIRHFGLFHRRSKQHAAAEQNANQIFSVSEGVARQQAEGPLERSIQLESRTLASRGDLNIPGLSEQCILVDHRERNTDSLGVQVSKRVCSFKSEKVVVEDTVPIIPKEKKHAKEEDSSADYDANLTDTITHEDYVTTRL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in adrenal gland. Lower expression in heart and retina. Also expressed in testis. Also expressed in testis. Also expressed in testis. The short isoform is specifically expressed in the adrenal gland

DOI ID

10.1002/j.1460-2075.1996.tb01004.x; 10.1016/s0014-5793(98)00041-6

RefSeq

NP_776903.1; XP_005213611.1; XP_010808964.1; XP_015329236.1; XP_015329237.1; XP_015329238.1